Therapy ought to be administered with warning, if whatsoever, to patients that are mentally depressed, have suicidal tendencies, or record of drug abuse
pentobarbital will enhance the stage or impact of clopidogrel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
pentobarbital will lower the extent or effect of erlotinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
buprenorphine transdermal and pentobarbital both improve sedation. Stay away from or Use Alternate Drug. Restrict use to clients for whom alternate therapy alternatives are insufficient
pentobarbital will lessen the extent or result of alosetron by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Mysterious.
pentobarbital will reduce the extent or influence of diazepam buccal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. Sturdy or moderate CYP3A4 inducers may perhaps enhance price of diazepam elimination; hence, efficacy of diazepam could possibly be diminished.
pentobarbital will lessen the level or impact of colchicine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
pentobarbital will minimize the level or outcome of fentanyl by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Carefully. Coadministration of fentanyl with CYP3A4 inducers may lead into a decrease in fentanyl plasma concentrations, deficiency of efficacy or, possibly, advancement of the withdrawal syndrome inside a client who's got developed Bodily dependence to fentanyl.
benzhydrocodone/acetaminophen and pentobarbital the two maximize sedation. Steer clear of or Use Alternate Drug. Restrict use to more info clients for whom choice cure possibilities are inadequate
pentobarbital will lessen the level or result of conjugated estrogens by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
pentobarbital will decrease the extent or effect of tramadol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Lessened AUC of tramadol along with the Lively metabolite (O-desmethyltramadol) when coadministered with robust CYP3A4 and CYP2B6 inducers
pentobarbital will increase toxicity of ifosfamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. CYP3A4 inducers may perhaps raise the metabolism of ifosfamide to its active alkylating metabolites.
Keep an eye on Carefully (one)pentobarbital will reduce the extent or effect of fentanyl transmucosal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Closely. Coadministration of fentanyl with CYP3A4 inducers may lead to your minimize in fentanyl plasma concentrations, lack of efficacy or, potentially, enhancement of a withdrawal syndrome within a client who may have developed physical dependence to fentanyl. Soon after halting a CYP3A4 inducer, as the results on the inducer drop, the fentanyl plasma concentration will improve which could enhance or lengthen both of those the therapeutic and adverse consequences.
Contraindicated (1)pentobarbital will minimize the level or effect of lumefantrine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration with powerful CYP3A4 inducers may result in reduced serum concentrations and lack of antimalarial efficacy